AMH Testing for Ovarian Reserve

AMH levels and fertilityPatients who are deferring their childbearing now have the AMH test to assess their ovarian reserve. There is some important news regarding AMH results.

To date there has been no clear proof that oral contraceptives can skew the results of the AMH test. The latest research is showing that continuous use of OC, transdermal and vaginal contraceptives DO affect the results – by as much as 50%. As you can see from the graph below, there is even a significant decrease in levels as early as after five weeks of contraceptive use.*

Another study** has shown that day seven of a hormone-free interval gives results which best correlate with natural cycles two months later. Ideally, it is best to test on the seventh hormone-free day. If the results are suppressed, you should test after being contraceptive free for two months for more accurate results.

* Kallio, Sanna, M.D., et al. “Antimullerian Hormone Levels Decrease in Women Using Combined Contraception Independently of Administration Route.” Fertility and Sterility 99.5 (2013): 1305-310.
** van den Berg MH, van Dulmen-den Broeder E, Overbeek A, Twisk JW, Schats R, van Leeuwen FE, Kaspers GJ, Lambalk CB. Comparison of ovarian function markers in users of hormonal contraceptives during the hormone-free interval and subsequent natural early follicular phases. Hum Reprod. 2010;25(6):1520-527.